SS-31 (10mg)

10 mg

We’ve named this remarkable peptide Revive, reflecting its profound ability to resurrect cellular energy at the source much like a master electrician that repairs the power grid of every cell thus restoring the fundamental energy production that drives vitality, longevity, and optimal function throughout the body.

What It Helps With

SS-31 stands as the premier mitochondrial-targeted therapy, offering sophisticated support for cellular energy dysfunction and age-related decline:

  • Mitochondrial dysfunction and impaired cellular energy production
  • Age-related fatigue and declining physical performance
  • Cardiovascular disease including heart failure and ischemic injury
  • Neurodegenerative conditions (Alzheimer’s, Parkinson’s, cognitive decline)
  • Primary mitochondrial myopathies and genetic mitochondrial disorders
  • Exercise intolerance and poor recovery from physical stress
  • Chronic kidney disease and acute kidney injury
  • Age-related macular degeneration and retinal disorders
  • Diabetic complications and metabolic dysfunction
  • Accelerated aging and cellular senescence

Mechanism of Action (The Science Behind It)

Let’s break down how SS-31 functions as your cellular powerhouse restorer. This unique tetrapeptide (D-Arg-2′,6′-dimethylTyr-Lys-Phe-NH2) represents a breakthrough in mitochondrial medicine, engineered with an alternating aromatic-cationic structure that allows it to selectively target and concentrate in the inner mitochondrial membrane at levels up to 5,000-fold higher than in surrounding tissues.

SS-31’s primary mechanism centers on its high-affinity binding to cardiolipin, a unique phospholipid found exclusively in the inner mitochondrial membrane. Cardiolipin is crucial for maintaining mitochondrial structure, organizing respiratory complexes into efficient supercomplexes, and facilitating optimal electron transport chain function. When mitochondria are damaged by age, disease, or oxidative stress, cardiolipin becomes peroxidized and loses its structural integrity.

By binding to cardiolipin through both electrostatic and hydrophobic interactions, SS-31 stabilizes mitochondrial membrane structure and prevents further oxidative damage. This stabilization allows the respiratory complexes to maintain their optimal arrangement, ensuring efficient ATP production while reducing harmful electron leakage that generates reactive oxygen species.

What makes SS-31 unique is its selective action on damaged mitochondria while leaving healthy mitochondria unaffected. The peptide also inhibits cytochrome c peroxidase activity, preventing the cascade of oxidative damage that leads to mitochondrial dysfunction and cellular death. This targeted approach restores cellular energy production from the ground up, addressing the fundamental cause of age-related decline and metabolic dysfunction.

Popular Use Cases

  • Mitochondrial Disease Treatment:
    Individuals with primary mitochondrial myopathies or genetic disorders affecting cellular energy production.
  • Anti-Aging and Longevity:
    Those seeking to address age-related mitochondrial decline and maintain cellular vitality.
  • Cardiovascular Health:
    Patients with heart failure, ischemic heart disease, or seeking cardiac protection during procedures.
  • Neurological Support:
    Individuals with neurodegenerative conditions or cognitive decline related to mitochondrial dysfunction.
  • Athletic Performance:
    Athletes experiencing exercise intolerance or seeking enhanced recovery and cellular energy optimization.
  • Chronic Disease Management:
    Those with conditions linked to mitochondrial dysfunction including diabetes, kidney disease, and metabolic disorders.

Dosage + Duration

Subcutaneous Injection Protocol:

  • Standard Dosing:
    5-10mg administered daily via subcutaneous injection
  • Clinical Protocols:
    Up to 40mg daily has been used safely in clinical trials
  • Mitochondrial Disease:
    10-40mg daily depending on severity and response
  • General Health Optimization:
    5-10mg daily for mitochondrial support
  • Acute Conditions:
    Higher doses (20-40mg) may be used short-term under medical supervision

Administration Timing:

  • Morning Preferred:
    To align with natural circadian energy patterns
  • Consistent Timing:
    Same time daily for optimal cellular adaptation
  • Protocol Duration:
    4-12 weeks for initial assessment, ongoing use as directed

Cycling Recommendations:

  • Continuous Use:
    Unlike many peptides, SS-31 can be used continuously without tolerance development
  • Assessment Periods:
    Regular evaluation of mitochondrial function markers and clinical response

Note: SS-31 has a plasma half-life of approximately 1-2 hours, but cellular effects persist much longer due to mitochondrial accumulation and membrane stabilization.

Side Effects

SS-31 demonstrates an exceptional safety profile from extensive clinical trials and research:

  • Mild Side Effects:
    Injection site reactions including erythema (57%), pruritus (47%), pain (20%), urticaria (20%), and irritation (10%)
  • Systemic Effects:
    Occasional dizziness, headache, or mild gastrointestinal discomfort
  • No Serious Adverse Events:
    Extensive clinical data shows no serious adverse reactions or fatalities
  • Excellent Tolerability:
    Well tolerated even at high doses up to 40mg daily
  • No Effect on Healthy Mitochondria:
    Selective action only on damaged or dysfunctional mitochondria

The peptide’s outstanding safety profile stems from its targeted mechanism and selective accumulation in mitochondria without affecting normal cellular functions.

Peptide Type

Classification: Mitochondrial-Targeted Antioxidant Tetrapeptide

SS-31 belongs to the Szeto-Schiller (SS) peptide family, featuring an alternating aromatic-cationic structure specifically designed for mitochondrial targeting and cardiolipin stabilization.

Number of Amino Acids

4 amino acids – This tetrapeptide contains the precise sequence necessary for selective mitochondrial targeting and cardiolipin binding: D-Arginine, 2′,6′-dimethyltyrosine, Lysine, and Phenylalanine.

FDA Status

Investigational Drug –

SS-31 (Elamipretide) has received FDA orphan drug designation for mitochondrial myopathy and is currently in advanced clinical trials. Not yet approved for general therapeutic use.

Experience Level

Intermediate to Advanced – SS-31 requires careful management due to its:

  • Specialized mitochondrial targeting mechanism requiring understanding of cellular bioenergetics
  • Clinical trial status and investigational nature
  • Potential applications in serious medical conditions requiring medical oversight
  • Best results when integrated with comprehensive mitochondrial health assessment
  • Higher dosing requirements compared to many other peptides

Popular Combinations (Stacks)

Mitochondrial Optimization Stack:

  • SS-31 + NAD+ precursors (comprehensive mitochondrial support and energy production)
  • SS-31 + CoQ10 (synergistic electron transport chain support)

Longevity and Anti-Aging Stack:

  • SS-31 + MOTS-c (mitochondrial membrane stability + metabolic optimization)
  • SS-31 + Humanin (cellular protection + mitochondrial function)

Cardiovascular Support Stack:

  • SS-31 + BPC-157 (mitochondrial protection + tissue repair)

Neurological Support Stack:

  • SS-31 + Cerebrolysin (mitochondrial function + neuroprotection)

Recovery and Performance Stack:

  • SS-31 + Thymosin Alpha-1 (cellular energy + immune optimization)

All combinations should be approached systematically with medical oversight, particularly given SS-31’s investigational status.

nudaLabs Clinical Note

In our nudaVitae protocols, SS-31 serves as the ultimate foundation for clients requiring deep cellular energy restoration and mitochondrial repair. We’ve observed consistently remarkable results in individuals with mitochondrial dysfunction, age-related decline, and treatment-resistant fatigue.

Key Biomarkers We Monitor:

  • Mitochondrial function markers (when available through specialized testing)
  • Energy metabolism indicators (lactate/pyruvate ratios, ATP production capacity)
  • Oxidative stress markers (8-hydroxy-2′-deoxyguanosine, malondialdehyde)
  • Inflammatory markers (CRP, IL-6, TNF-alpha)
  • Cardiovascular function (if indicated)
  • Cognitive assessment scores (for neurological applications)
  • Physical performance metrics (exercise tolerance, fatigue scores)

Clinical Insights: Our most successful SS-31 protocols combine precise dosing with comprehensive mitochondrial support strategies. We’ve found that clients who pair SS-31 with optimized nutrition, targeted supplementation (NAD+ precursors, CoQ10), and appropriate exercise protocols see dramatically enhanced outcomes. The peptide seems to unlock cellular energy production that has been compromised by age, disease, or genetic factors.

Notable Case Pattern: We frequently see remarkable responses in clients with longstanding fatigue, exercise intolerance, and neurodegenerative conditions. SS-31 often serves as the missing piece that allows other therapeutic interventions to work effectively by addressing the fundamental issue of mitochondrial dysfunction at the cellular level.

Product Specifications & Quality Assurance

nudaLabs SS-31 (10mg) Vial Specifications:

Molecular Information:

  • CAS Number: 736992-21-5
  • Molecular Weight: 639.8 Da
  • Molecular Formula: C32H49N9O5
  • Amino Acid Sequence: D-Arg-2′,6′-dimethylTyr-Lys-Phe-NH2
  • Alternative Names: Elamipretide, MTP-131, Bendavia
  • Peptide Classification: Mitochondrial-targeted antioxidant tetrapeptide

Quality Standards:

  • Purity: ≥99% (verified by HPLC-MS)
  • Appearance: White to off-white lyophilized powder
  • Solubility: Highly water-soluble for optimal bioavailability
  • Endotoxin Level: <1.0 EU/mg
  • Manufacturing: USA facility under ISO 9001:2015 standards
  • Synthesis Method: Solid Phase Peptide Synthesis (SPPS)

Storage & Handling:

  • Storage Temperature: Room temperature or 2-8°C before reconstitution
  • Shelf Life: 24 months when stored properly and protected from light
  • Reconstituted Storage: 2-8°C (refrigerator) for up to 4 weeks
  • Recommended Reconstitution: Bacteriostatic water at 5-10mg/mL concentration

Quality Control Testing: Every batch undergoes comprehensive analysis including:

  • High-Performance Liquid Chromatography (HPLC) for purity verification
  • Mass Spectrometry (MS) for molecular weight confirmation
  • Amino acid analysis for sequence verification
  • Endotoxin testing for safety assurance
  • Biological activity assays for cardiolipin binding affinity
  • Sterility testing where applicable

Administration Guidelines:

  • Injection Type: Subcutaneous injection using insulin syringes (29-31 gauge)
  • Injection Sites: Rotate between abdominal areas, arms, or thighs
  • Timing: Morning administration preferred for energy optimization
  • Preparation: Gentle reconstitution to maintain peptide integrity
  • Medical Coordination: Regular monitoring recommended for optimal dosing and safety

Compliance & Safety:

  • Research Use Only: This product is intended for laboratory research purposes only
  • Not for Human Consumption: Not approved for therapeutic, diagnostic, or human use
  • FDA Status: Investigational drug with orphan designation for mitochondrial myopathy
  • Batch Tracking: Each vial includes unique lot numbers and QR codes for full traceability
  • Certificate of Analysis (COA): Available for each batch upon request

SS-31 represents the pinnacle of mitochondrial medicine, offering targeted cellular energy restoration that works at the most fundamental level of cellular function.

When integrated thoughtfully into comprehensive health optimization protocols, it offers the potential to restore energy production, enhance cellular resilience, and address the root cause of age-related decline, mitochondrial dysfunction. This represents not just symptom management, but true cellular regeneration from the powerhouse level.

Are your peptides safe and lab-tested?

Yes. Every peptide we offer is sourced from FDA-registered compounding pharmacies or ISO-certified research laboratories that uphold the highest standards of purity, sterility, and identity verification. Each batch undergoes rigorous third-party testing for contaminants, potency, and peptide sequence accuracy. While peptides are not FDA approved for general medical use unless explicitly indicated, they are widely used under the regulatory classification of compounded or research compounds. At nudaLabs, we only work with vetted providers whose testing protocols and safety data meet or exceed regulatory expectations. Your safety is our baseline. Our protocols are built on trust, transparency, and clinically responsible use. This is the nuda way.

In some cases, yes. Some therapeutic peptides require a prescription and are dispensed through licensed compounding pharmacies. However, certain peptides are legally classified as “research-use only,” meaning they may be sold without a prescription depending on your jurisdiction and intended use. At nudaLabs, we guide you through this landscape with precision and integrity. Our process begins with the first clinically integrated AI tool for peptide protocol personalization (called the nudaVitae – include link here). It is designed to align your biology, goals, and safety profile with the peptides best for your body. We also offer optional telehealth consultations with peptide consultants to ensure medical appropriateness, compliance, and clarity. Whether your protocol involves prescription compounds or research peptides, our care team will walk with you every step of the way, prioritizing safety, legality, and personalized optimization.

<p>All peptides are shipped directly from licensed U.S. pharmacies or ISO-certified labs to our facility in Bentonville, Arkansas, and then to your door in secure, temperature-controlled packaging. If the peptide requires cold-chain integrity (such as lyophilized powders or reconstituted vials), your order will include cold packs or insulated materials to maintain stability during transit. Most peptides are stable at room temperature for short durations, but we recommend immediate refrigeration upon arrival. Shipping includes detailed instructions for storage, handling, and reconstitution (if applicable). For added protection, tracking numbers and insurance are included with every shipment. At this time, we do not ship outside the United States.</p>

All peptides are shipped directly from licensed U.S. pharmacies or ISO-certified labs to our facility in Bentonville, Arkansas, and then to your door in secure, temperature-controlled packaging. If the peptide requires cold-chain integrity (such as lyophilized powders or reconstituted vials), your order will include cold packs or insulated materials to maintain stability during transit. Most peptides are stable at room temperature for short durations, but we recommend immediate refrigeration upon arrival. Shipping includes detailed instructions for storage, handling, and reconstitution (if applicable). For added protection, tracking numbers and insurance are included with every shipment. At this time, we do not ship outside the United States.

That’s exactly why nudaLabs exists. Rather than guessing or buying blindly, we invite you to complete a short intake and schedule a clinical consult through our platform. From there, we create your personalized nudaVitae, an elegant, biologically aligned peptide protocol based on your health history, goals, labs, and lifestyle. Whether you’re new to peptides or refining an existing protocol, our team tailors every recommendation with precision. The right peptide isn’t just about symptoms; it’s about rhythm, recovery, and the deeper story your body is telling. We help you listen.

We welcome thoughtful, patient-centered providers into our clinical and compounding network. If you’re interested in offering nuda protocols to your patients or integrating our peptides into your practice, your first step is to fill out our Provider Partnership Application [insert link]. Once submitted, our medical team will schedule a discovery call to explore alignment, licensing, fulfillment logistics, and collaborative care models. We offer white-labeled protocols, access to nuda-branded education, and optional telehealth coverage if needed. At nudaLabs, we don’t just distribute peptides we are building an ecosystems of care around them (technology, education, consultation, and implementation).

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